C825T Polymorphism of the G Protein β 3 -Subunit and Antihypertensive Response to a Thiazide Diuretic
نویسندگان
چکیده
منابع مشابه
WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic.
Single nucleotide polymorphisms (SNPs) in genes encoding or influencing renal sodium transport systems were investigated as potential predictors of blood pressure (BP) response to a thiazide diuretic. A sample of 585 adults with essential hypertension (30 to 59.9 years of age; 50% blacks; 47% women) were treated with hydrochlorothiazide for 4 weeks (25 mg daily, orally) to determine office BP r...
متن کاملGenomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
We conducted a genome-wide association study to identify novel genes influencing diastolic blood pressure (BP) response to hydrochlorothiazide, a commonly prescribed thiazide diuretic preferred for the treatment of high BP. Affymetrix GeneChip Human Mapping 100K Arrays were used to measure single nucleotide polymorphisms across the 22 autosomes in 194 non-Hispanic black subjects and 195 non-His...
متن کاملThe human G protein beta 3 subunit GNB3 825T polymorphism.
Meirhaeghe et al. recently showed that the T allele of a C vs T exchange at position 825 of the gene encoding for the beta3 subunit of heterotrimeric G proteins (GNB3) is associated with enhanced coronary constriction after intracoronary administration of methylergonovine. The 825T allele has also been shown to be associated with an enhanced response after activation of G protein coupled recept...
متن کاملAssociation between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects.
PURPOSE The G-protein β3-subunit gene C825T polymorphism (GNB3-C825T) has been reported to be associated with essential hypertension (EH), but results from previous studies are conflicting. The present study aimed at investigating the association between this polymorphism and risk of EH using a meta-analysis on the published studies. MATERIALS AND METHODS PubMed, Embase, CBM (China Biological...
متن کاملG-Protein Beta3 Subunit C825T Polymorphism in Patients With Overlap Syndrome of Functional Dyspepsia and Irritable Bowel Syndrome
BACKGROUND/AIMS Guanine nucleotide binding protein (G-protein) beta polypeptide 3 (GNB3) C825T polymorphism alters intracellular signal transduction, which may lead to motor or sensory abnormalities of the gastrointestinal tract. The aim of the present study was to evaluate the association of the GNB3 C825T polymorphism with susceptibility to overlap syndrome of functional dyspepsia (FD) and ir...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2001
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.37.2.739